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| Nadal,Jessica; Pedroso,Flávia de B.; Minozzo,Bruno Rodrigo; Brito,Priscilla Salles de; Farago,Paulo Vitor; Vellosa,José Carlos Rebuglio; Miyoshi,Edmar. |
| ABSTRACT Ferulic acid (FA) is a phenolic compound with well-known antioxidant potential that can be used as a promising anti-inflammatory and anti-cancer molecule. Furthermore, it has been reported to have neuroprotective activity. One of the main problems, which limit its clinical use, is its low bioavailability when administered orally. This limitation can be circumvented by changes in their structure and/or for preparing lipid-based formulations. The aim of this study was to synthesize a derivative of FA, the hexadecyl ferulate (HF). This compound would be more susceptible to pass through blood-brain barrier (BBB) due to its lipophilic character. The HF was obtained by Steglich esterification and yielded 76.77 ± 1.35%. Its structural characterization... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ABTS•+ assay; DPPH• assay; Ferulic acid derivative; Scavenger activity; Steglich esterification. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100428 |
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| Vecchia,Débora Dalla; Schamne,Marissa Giovanna; Ferro,Marcelo Machado; Santos,Ana Flávia Chaves dos; Latyki,Camila Lupepsa; Lara,Danilo Vieira de; Ben,Juliana; Moreira,Eduardo Luiz; Prediger,Rui Daniel; Miyoshi,Edmar. |
| Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in the (substantia nigra pars compact). Hypericum perforatum (H. perforatum) is a plant widely used as an antidepressant, that also presents antioxidant and anti-inflammatory properties. We evaluated the effects of H. perforatum on the turning behavior of rats submitted to a unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle as an animal model of PD. The animals were treated with H. perforatum (100, 200, or 400 mg/kg, v.o.) for 35 consecutive days (from the 28th day before surgery to the 7th day after). The turning behavior was evaluated at 7, 14 and 21 days after the surgery,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson's disease/treatment/experimental study; H. perforatum/phytotherapy/neuroprotective effect; Turning behavior; 6-OHDA. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100111 |
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